Nf-Kb(P50)₂ Complexed To A High- Affinity RNA Aptamer

The Nf-Kb(p50)₂ protein is a Kappa-B transcription factor consisting of two p50 DNA-binding subunits.  Each subunit binds DNA via two beta-barrel structures.  The p50 homodimer plays many physiological roles, including regulation of inflammatory responses and is involved in cellular apoptosis.  In this structure, Nf-Kb(p50)₂ is bound to two high affinity RNA Aptamers.

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Protein-RNA Aptamer Complex

     Backbone

Nf-Kb(p50)₂

     p50 Subunits

        p50 Subunits Only

     p50 Subunits, Backbone

        p50 Secondary Structure

RNA Strands

      RNA Subunits

        RNA Subunits Only

p50-RNA Complex

     p50 Subunit

      p50 Subunit Binding Site (press twice)

      p50 Beta barrel-RNA interaction

      p50-RNA Binding (press twice)