1. To understand the function of the digestive system on an organismal level, and in terms of individual organs
2. To become familiar with the structure of the components of the digestive system.
Introduction
To get food (a collection of organic molecules minerals and water) from the environment to our cells we must:
Ingest it -- take it in from the environment, so that we canDigest it -- break it down both physically and chemically, so that we can
Absorb it -- move it across a surface from the environment to our interstitial fluid. The part of food that cannot be absorbed is eliminated (egested) and returned to the environment.
Digestion
physical digestion -- increases the surface area of food so that it can be broken down chemically
- chewing
- churning
- emulsification.
chemical digestion
Molecules in food are broken down into their components by hydrolysic enzymes, which break polymers into monomerssome are polymers (made up of repeating subunits, or monomers): polymer Æ monomers
Carbohydrates: polysaccharides Æ monosaccharidesProteins: polypeptides Æ amino acids
Nucleic acids: nucleic acids Æ nucleotides
Fats aren't
Fats: triacylglyceride Æ glycerol + 3 fatty acidsOnce digested, the components of large food molecules can be reassembled into our molecules
Oral cavity
function:ingestion and digestion (chewing)structure:
tongue, teeth, etcsecretions:
saliva, which contains salivary amylases and mucincontrol:
voluntaryabsorption:
none
Pharynx (throat)
function:swallowing, getting the bolus of food down the esophagus without going through the glottis down the tracheastructure:
epiglottis covers the glottis (see diagrams in book)secretions:
nonecontrol:
involuntaryabsorption:
none
Esophagus
function:get food to stomach from pharynxstructure:
muscular tube with sphincters at either endsecretions:
nonecontrol:
involuntary peristalsisabsorption:
none
Stomach
function:storage, DIGESTION -- physical and chemical breakdown of food, sterilizes foodproteins, especially collagens, are hydrolyzed here
structure:
muscular sac with sphincters at either end, glandular tissue in epithelium (see pictures in book)secretions:
HCl, pepsin (as pepsinogen), mucusWhy doesn't the stomach digest itself?....
absorption:
not much; water, salts, some drugs such as aspirin and alcoholcontrol:
food in stomach stimulates the secretion of gastrin, which stimulates stomach secretions
Small Intestine
function:DIGESTION and ABSORPTIONstructure:
duodenum, jejunum, ileum : a long muscular tube with sphincters at either end (see pictures in book). Large surface areaPancreas and liver (w/ gall bladder) release secretions via a duct that empties into the duodenum.
secretions:
liver:bile, an emulsifier -- stored in gall bladderpancreas:
sodium bicarbonatehydrolytic enzymes -- amylases, nucleases, lipases, proteases
absorption:
Most small molecules (monomers) are absorbed into blood stream, some fats taken up by lacteals into lymphatic system. Water and ions are also absorbed here.control:
3 hormones -- secretin, choleocystokinin (CCK) and gastric inhibitory peptide (GIP) -- regulate digestion by the small intestine
Large intestine
function:ABSORPTION; chyme becomes fecesstructure:
muscular tube with sphincters at either end (see pictures in book)secretions:
none, usuallyabsorption:
water, ions and vitamins -- dysfunction can cause diarrheaA large bacterial flora occupies the colon, manufacturing some vitamins (e.g., K), as well as gases...
Note:
some animals such as cows, horses, rabbits and termites use a microbial community in their guts to break down cellulose, etc.
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